He was 23 of 45 for 309 yards with a 4-yard TD pass to Donnie Avery early in the fourth. But Luck also got picked off three times twice by Tim Jennings in an up-and-down start for a rookie with huge shoes to fill. All he has to do is prove the Colts were right to take him with the No. 1 pick in the draft and part with Peyton Manning after he missed last season with a neck injury.
Reggie Wayne, one of Manning's old targets, caught nine passes for 135 yards. But it was a familiar result for a team with new management and a new coach in Chuck Pagano after winning just two games.
Then again, it was hardly a surprise.
The Bears are aiming high, and they wound up with their highest point total since they scored 48 in a win over Detroit on Oct. 4, 2009.
With their Pro Bowl running back and strong-armed quarterback leading the way, they racked up 428 yards 287 while building a 10-point halftime lead in their first game with Mike Tice as coordinator.
Forte's 6-yard run early in the third quarter and Robbie Gould's field goal after LaVon Brazill fumbled away the ensuing kickoff made it 34-14.
Cutler shook off a rough start and completed 21 of 35 passes. He got sacked by Robert Mathis for a 12-yard loss on the game's first play from scrimmage, a familiar site for the Bears, and had an interception returned 3 yards for a touchdown by Jerrell Freeman on the second possession. But Chicago caught a big break when the Colts' Dwight Freeney sprained an ankle in the first quarter.
The Bears are eyeing a playoff run after injuries wrecked a promising season a year ago, sending them to an 8-8 finish. New general manager Phil Emery revamped the roster and brought in a go-to receiver, reuniting Cutler with his old friend from Denver in Marshall in that blockbuster trade with Miami.
One big concern is Brian Urlacher's left knee after he initially injured it in the finale last season and had it scoped last month. The eight-time Pro Bowl linebacker practiced this week for the first time since July 31 and got pulled from this game after things got out of hand.
Pro Bowl cornerback Charles Tillman limped off the field and appeared to be favoring his right leg after Indianapolis punted on its first possession. He came back for the next defensive series but sat out the rest of the way.
The Colts were missing receiver Austin Collie, who was held out because of a concussion, and their defense took a hit when Freeney rolled his ankle on a low block early in the game.
That happened on the Bears' first scoring drive, which wiped out a 7-0 deficit and quieted the groans that were rumbling through Soldier Field.
That sack on Cutler was an all-too-familiar sight, and Freeman's touchdown return on a short swing pass intended for Forte to start the second possession wasn't what the Bears had in mind.
They quickly erased that deficit, with a 32-yard run around the left end by Forte and a 15-yard spin through the middle leading to Bush's 1-yard scoring run. And they grabbed a 14-7 lead early in the second quarter on Cutler's 3-yard pass to Marshall. That came after a neat one-handed grab by Forte, who leapfrogged a defender while turning a short pass into a 31-yard gain.
A deep pass by Luck intended for Donnie Avery got picked off by a leaping Tim Jennings. That led to a field goal by Gould, making it a 10-point game, before an 18-yard run by Donald Brown late in the half pulled Indianapolis within 17-14.
Bush's scoring run from the 1 in the closing minute of the half made it 24-14 and it stayed that way when the Colts' Adam Vinatieri missed a 37-yard field goal in the final seconds.
Indianapolis 21, Chicago 41
Indianapolis 7 7 0 7 21
Chicago 7 17 10 7 41
Ind • Freeman 4 interception return (Vinatieri kick), 11:23.
Chi • Bush 1 run (Gould kick), 7:19.
Chi • Marshall 3 pass from Cutler (Gould kick), 10:33.
Chi • FG Gould 35, 5:32.
Ind • D.Brown 18 run (Vinatieri kick), 3:17.
Chi • Bush 1 run (Gould kick), :44.
Chi • Forte 6 run (Gould kick), 11:52.
Chi • FG Gould 26, 10:02.
Ind • Avery 4 pass from Luck (Vinatieri kick), 10:20.
Chi • Jeffery 42 pass from Cutler (Gould kick), 6:08.
Attendance • 62,341.
First downs 22 26
Total Net Yards 356 428
Rushes-yards 15-63 33-114
Passing 293 314
Punt Returns 2-12 1-23
Kickoff Returns 4-73 2-49
Interceptions Ret. 1-4 3-63
Comp-Att-Int 23-45-3 21-35-1
Sacked-Yards Lost 3-16 2-19
Punts 5-51.4 5-41.6
Fumbles-Lost 2-2 0-0
Penalties-yards 3-19 7-48
Time of Possession 24:32 35:28
Rushing • Indianapolis, D.Brown 9-48, Luck 2-9, Ballard 4-6. Chicago, Forte 16-80, Bush 12-42, Cutler 4-(minus 4), Hester 1-(minus 4).
Passing • Indianapolis, Luck 23-45-3-309. Chicago, Cutler 21-35-1-333.
Receiving • Indianapolis, Wayne 9-135, Fleener 6-82, Avery 3-37, Adams 2-26, Moore 1-11, Brazill 1-10, Jones 1-8. Chicago, Marshall 9-119, Jeffery 3-80, Bennett 3-50, Forte 3-40, Hester 2-27, Adams 1-17.
Missed Field Goals • Indianapolis, Vinatieri 37 (WR).