Flacco overthrew Ray Rice on fourth-and-1 from the Ravens 46, and the Eagles ran out the clock.
Vick threw four interceptions at Cleveland last week, but rallied the Eagles (2-0) to a 17-16 win.
He did it again, though the replacement officials almost made a costly mistake.
Down 23-17, the Eagles started at their 20 with 4:43 left. Vick threw passes of 24 and 13 yards to Brent Celek. A 19-yard pass to Clay Harbor coupled with a roughing-the-passer penalty put the ball at the 3.
Vick then threw incomplete as he was being hit by Haloti Ngata, but the play was ruled a fumble. It was recovered by the Ravens, but replay overturned the call and Vick scored on the next play.
The Eagles committed three turnovers in the red zone in the first half and lost two starting offensive linemen in the second.
Vick finished 23 of 32 for 371 yards with one touchdown and two interceptions. Celek had eight catches for 157 yards and DeSean Jackson had seven receptions for 114 yards.
This was a homecoming of sorts for Flacco and Ravens coach John Harbaugh. Flacco grew up in nearby Haddon Township, N.J. Harbaugh spent 10 seasons as an assistant under Andy Reid before going to Baltimore in 2008.
Tucker almost made them winners.
An undrafted rookie out of Texas, Tucker beat out veteran kicker Billy Cundiff in the preseason and has made all six of his field goals in the first two games.
Tucker's 56-yarder at the end of the first half sent the Ravens into the locker room up 17-7. His 51-yarder early in the fourth made it 17-14.
Cundiff was 1-for-6 from beyond 50 yards last year, and missed a potential game-tying, 32-yarder against New England in the waning seconds of the AFC championship game.
Two plays after center Jason Kelce sprained his right knee and was carted back to the locker room, the Eagles got within 17-14 on Vick's 23-yard TD pass to Jeremy Maclin. Vick scrambled to his left and threw on the run to Maclin, who slipped behind coverage and went to his knees to make a nifty catch.
Philadelphia lost two more starters on its next drive. First, King Dunlap left with a hamstring injury. Maclin was then carted off with a hip pointer after making a block on Celek's 24-yard catch. Still, the Eagles reached the 5 before settling for Alex Henery's tying 23-yard field goal.
The starting quarterbacks were coming off opposite performances in Week 1. While Vick struggled against the Browns, Flacco was near-flawless in a dominant 44-13 win against Cincinnati last Monday night.
Flacco was 22 of 42 for 232 yards, one TD and one interception against the Eagles.
Using the no-huddle from the start, the Eagles moved the ball effectively to the Ravens 12. But Vick made another errant throw and was intercepted in the end zone by Bernard Pollard. Vick scrambled out of the pocket and had space, but he fired opposite his momentum.
Trent Cole stripped Flacco on Baltimore's second play and Cullen Jenkins recovered at the Ravens 15.
McCoy ran in from the 1 for a 7-0 lead.
Vonta Leach scored on a 5-yard TD run to tie it at 7.
After the Ravens failed to convert on a fake punt Sean Considine ran 3 yards on fourth-and-4 the Eagles took over at Baltimore's 45. The drive ended in another turnover. Rookie Bryce Brown fumbled a handoff on third-and-1 at the 20, and Albert McClellan recovered at the 30.
Flacco connected with Jacoby Jones on a 21-yard TD pass to give the Ravens a 14-7 lead.
The Eagles drove to the Ravens 9 before Lardarius Webb caused McCoy to fumble. Ray Lewis recovered and was slammed down to the ground by Vick.
McCoy had one fumble last year when he was an All-Pro. He already has lost two in two games.
Baltimore 23, Philadelphia 24
Baltimore 7 10 0 6 23
Philadelphia 7 0 10 7 24
Phi • McCoy 1 run (Henery kick), 5:40.
Bal • Leach 5 run (Tucker kick), 2:08.
Bal • J.Jones 21 pass from Flacco (Tucker kick), 8:32.
Bal • FG Tucker 56, :01.
Phi • Maclin 23 pass from Vick (Henery kick), 10:40.
Phi • FG Henery 23, 5:30.
Bal • FG Tucker 51, 11:28.
Bal • FG Tucker 48, 4:43.
Phi • Vick 1 run (Henery kick), 1:55.
Attendance • 69,144.
First downs 17 26
Total Net Yards 325 486
Rushes-yards 21-111 41-129
Passing 214 357
Punt Returns 3-34 3-10
Kickoff Returns 3-100 3-49
Interceptions Ret. 2-9 1-0
Comp-Att-Int 22-42-1 23-32-2
Sacked-Yards Lost 2-18 2-14
Punts 5-50.2 5-39.2
Fumbles-Lost 1-1 2-2
Penalties-yards 6-45 7-58
Time of Possession 25:39 34:21
Rushing • Baltimore, Rice 16-99, Leach 1-5, Pierce 3-4, Considine 1-3. Philadelphia, McCoy 25-81, Vick 10-34, Brown 3-7, D.Johnson 1-6, Havili 2-1.
Passing • Baltimore, Flacco 22-42-1-232. Philadelphia, Vick 23-32-2-371.
Receiving • Baltimore, Pitta 8-65, Rice 6-53, T.Smith 2-51, Boldin 2-7, Dickson 1-23, J.Jones 1-21, Doss 1-6, Leach 1-6. Philadelphia, Celek 8-157, Jackson 7-114, Avant 2-33, McCoy 2-8, Maclin 1-23, Harbor 1-19, D.Johnson 1-13, Havili 1-4.
Missed Field Goals • None.