Four days after rallying from 14 points down to beat Tampa Bay, the Giants dominated the first half, scoring on their first four possessions to build a 20-0 lead.
The defending champion Giants (2-1) were without three starters but it hardly mattered.
Brown waived by five different teams, including the Panthers, since coming into the league as a fourth-round draft pick in 2009 got his chance Thursday night when Ahmad Bradshaw sat out with a neck injury.
Brown said he thought about getting cut by the Panthers before the game and it inspired him.
"I was walking into the stadium and I have to go by the spot where I parked my car," Brown said. "I felt a little fire, no doubt. I'm so happy to come out here. It really humbled me. It really shows that everything is not guaranteed. You know, I'm just going to ride this wave. Hopefully, it's a long wave."
Ramses Barden is hoping to ride that same wave.
Barden caught nine passes for a career-high 138 yards in his first NFL start. He played in place of Hakeem Nicks.
Of course it helps that the guy throwing you the ball is named Manning. He completed 27 of 35 passes for 288 yards with one touchdown and no interceptions.
On the other side, second-year quarterback Cam Newton struggled all night and was pressured into three interceptions. The Panthers (1-2) had five turnovers, including two by returner Joe Adams.
Newton had no luck running the read option against the Giants. He was held to 6 yards rushing a week after running for a career-high 71 yards against the Saints.
"We got some licks on him, when he kept the ball, and that's something that was lacking last week," Giants coach Tom Coughlin said. "You have to be disciplined. You have to have people in the right spots, or he'll take full advantage of it."
Panthers coach Ron Rivera likened the loss to a lesson you learn from your big brother.
"They came in and slapped us around and dragged us to the ground a little bit," Rivera said. "Hopefully, we learn from it a little bit. Hopefully, we learn from it and, hopefully, we don't like it and we come back focused."
Mixing run and pass, the Giants dominated the opening half, outgaining the Panthers 303-125.
Manning completed 19 of 25 passes for 208 yards in the first half, including a 14-yard touchdown pass to Martellus Bennett to cap the Giants' game-opening drive and set the tone.
It capped an eight-play, 80-yard drive and marked the third straight game the Panthers have given up a touchdown on an opponent's first drive.
Storylines New York state of mind
R New York's Andre Brown rushes for a career-high 113 yards and two touchdowns.
• Giants QB Eli Manning completes 27 of 35 passes for 288 yards and a TD.
• Ramses Barden catches nine passes for 138 yards in his first start.