That leaves the Jets without their best players on defense and offense as they try to return to the playoffs this year.
Holmes went down on the first play of the fourth quarter of the Jets' 34-0 loss to San Francisco on Sunday after catching a short pass. X-rays on the foot were negative, meaning there were no broken bones, but the MRI exam results were sent to a foot specialist in North Carolina and the Jets' worst fears were confirmed.
Ryan confirmed that it is a Lisfranc injury, which usually involves a sprain or tear of the ligament in the middle of the foot that holds the first two toes together. Recovery time depends on whether there is a dislocation or fracture, and whether surgery is needed.
Around the league
Titans • Jake Locker's dislocated non-throwing shoulder is sore enough that Tennessee doesn't even want him dressing Sunday when it visits Minnesota, so veteran Matt Hasselbeck will start at quarterback.
Texans • Houston cut third-string quarterback John Beck and re-signed safety Troy Nolan. The 31-year-old Beck, a former BYU star, signed with Houston in May after he was cut by Washington. The Texans (4-0) turned to Nolan after Quintin Demps fractured his left forearm Sunday.
Saints • The NFL has granted permission for coach Sean Payton, general manager Mickey Loomis and assistant head coach Joe Vitt to attend New Orleans' home game Sunday night against San Diego, in which Drew Brees can break a tie with Johnny Unitas for the NFL record of consecutive regular-season games with a touchdown pass.
Week 5 schedule
Arizona at St. Louis, 6:20 p.m., NFL Network
Baltimore at Kansas City, 11 a.m., Ch. 2
Atlanta at Washington, 11 a.m.
Philadelphia at Pittsburgh, 11 a.m.
Green Bay at Indianapolis, 11 a.m.
Cleveland at N.Y. Giants, 11 a.m.
Miami at Cincinnati, 11 a.m.
Seattle at Carolina, 2:05 p.m.
Chicago at Jacksonville, 2:05 p.m.
Buffalo at San Francisco, 2:25 p.m.
Tennessee at Minnesota, 2:25 p.m.
Denver at New England, 2:25 p.m., Ch. 2
San Diego at New Orleans, 6:20 p.m., Ch. 5
Open: Dallas, Detroit, Oakland, Tampa Bay
Houston at N.Y. Jets, 6:30 p.m., ESPN