Ryan finished 22 of 29 for 262 yards and three TDs for his first win against his hometown team in three tries.
Michael Vick didn't turn the ball over for once, but he played so-so and failed to beat his former team in his second start against the Falcons since returning to the NFL in 2009.
The Falcons scored on their first six possessions before punting for the first time with 5:35 left.
This was a validation win for Atlanta. The Falcons entered with no victories over a team with a winning record and their opponents were a combined 13-24 going into this weekend. Perhaps that's why they were a surprising 3-point underdog despite Philadelphia's recent struggles.
Reid's Eagles have lost three in a row since starting 3-1. Reid fired Juan Castillo and replaced him with Bowles two days after Philadelphia blew its second straight fourth-quarter lead in an overtime loss to Detroit.
Clearly, it didn't work.
Castillo's defense allowed 18.5 points per game, excluding two TD returns against the offense. Bowles' D allowed 21 points in the first 24 minutes and couldn't make a stop until the fourth quarter.
A sellout crowd anticipating a pending storm expected to hit the East Coast soon started filtering out in the third quarter. Those who stuck around booed the Eagles off the field, though one guy chanted "E-A-G-L-E-S" in the final minute.
The anti-Reid fans may be seeing him in his final months with the team. Owner Jeffrey Lurie already stated before the season that another 8-8 finish would be "unacceptable."
The Falcons methodically drove 80 yards on 16 plays on the opening possession, converting five third downs. A holding call on defensive end Jason Babin kept the drive going after Ryan threw an incomplete pass on third-and-10. Ryan then threw a 15-yard TD pass to Drew Davis for a 7-0 lead.
Ryan tossed a 3-yard TD pass to Jason Snelling to make it 14-0. Penalties on Dominique Rodgers-Cromartie and Mychal Kendricks on separate third downs kept Atlanta's drive going.
After going three-and-out on the first series, the Eagles put it together on the next drive by mixing in seven runs among their 13 plays. LeSean McCoy scored from the 2 to cut it to 14-7.
But the Falcons answered quickly. Ryan connected with Julio Jones over Nnamdi Asomugha for the 63-yard score to put Atlanta up 21-7.
Atlanta converted their first nine third-down tries, including three by penalty. The Eagles finally held in the final minute of the second quarter and Matt Bryant's 43-yard field goal gave the Falcons a 24-7 halftime lead. Bryant kicked field goals of 29 and 30 on the next two drives.
The Eagles made it 30-17 on Vick's 7-yard TD pass to McCoy in the fourth quarter.
Atlanta 30, Philadelphia 17
Atlanta 14 10 3 3 30
Philadelphia 0 7 3 7 17
Atl • Dr.Davis 15 pass from Ryan (Bryant kick), 6:16.
Atl • Snelling 3 pass from Ryan (Bryant kick), :32.
Phi • McCoy 2 run (Henery kick), 8:18.
Atl • Jones 63 pass from Ryan (Bryant kick), 6:33.
Atl • FG Bryant 43, :02.
Phi • FG Henery 33, 11:20.
Atl • FG Bryant 29, 6:10.
Atl • FG Bryant 30, 14:57.
Phi • McCoy 7 pass from Vick (Henery kick), 7:18.
Attendance • 69,144.
First downs 24 20
Total Net Yards 392 270
Rushes-yards 37-146 24-92
Passing 246 178
Punt Returns 1-11 1-7
Kickoff Returns 2-30 5-89
Interceptions Ret. 0-0 0-0
Comp-Att-Int 22-29-0 21-35-0
Sacked-Yards Lost 2-16 3-13
Punts 2-26.0 3-48.0
Fumbles-Lost 1-0 2-0
Penalties-yards 6-40 6-57
Time of Possession 32:55 27:05
Rushing • Atlanta, Rodgers 8-60, Turner 24-58, Ryan 3-18, Jones 1-9, Snelling 1-1. Philadelphia, McCoy 16-45, Vick 7-42, Brown 1-5.
Passing • Atlanta, Ryan 22-29-0-262. Philadelphia, Vick 21-35-0-191.
Receiving • Atlanta, Jones 5-123, Rodgers 5-20, White 3-38, Gonzalez 3-29, Snelling 3-16, Dr.Davis 2-30, Turner 1-6. Philadelphia, Maclin 6-33, Jackson 5-59, Avant 4-45, Celek 3-32, McCoy 3-22.
Missed Field Goals • None.