Brown, filling in for injured running back LeSean McCoy, surpassed Correll Buckhalter's rookie mark of 134 yards rushing in his first start since his senior year at Wichita East High School in 2008. But Brown also lost two fumbles, including one in Panthers' territory.
Fellow rookie Nick Foles was so-so in his second straight start for Michael Vick, who also sat out with a concussion. Foles was 16 of 21 for 119 yards.
Carolina (3-8) went ahead 24-22 early in the fourth quarter on Graham Gano's 23-yard field goal.
Then the Panthers finally stopped Brown when it mattered most, stuffing him on a fourth-and-1 to take over on downs at their 40. Newton led them downfield, running in from the 2 to make it 30-22. Gano, signed last week, missed the extra point. But Brandon Boykin fumbled after a 44-yard kickoff return, the Panthers recovered and held the ball the final 4:29.
Newton, who hadn't played up to his sensational rookie season, showed no signs of a sophomore slump against Philadelphia's porous pass defense. He finished 18 of 28 for 306 yards.
Newton had a 24-yard TD toss over the middle to a wide-open Gary Barnidge for a 7-3 lead. He connected with Brandon LaFell on a 43-yard pass to make it 14-3 later in the first quarter. LaFell was wide open on the play, taking advantage of another breakdown in coverage in the secondary.
Since Todd Bowles replaced Juan Castillo as defensive coordinator, the Eagles have allowed 13 passing touchdowns and haven't had an interception in five games.
Newton led a 95-yard drive to open the third quarter, finishing it off with a 1-yard leap to give the Panthers a 21-15 lead. Newton hit Louis Murphy for a 55-yard gain on a second-and-11 from Carolina's 16.
A 51-yard pass interference call on Haruki Nakamura on Foles' deep pass to Jeremy Maclin put Philadelphia at the Panthers 5. Brown then ran in for the go-ahead score.
Brown broke loose early in the second quarter to get Philadelphia within 14-12. Brown started up the middle, cut outside and outran the defense down the right sideline for the seventh-longest TD run by a Philadelphia rookie. The Eagles inexplicably tried a 2-point conversion and failed.
Alex Henery's 45-yard field goal gave them a 15-14 lead. Henery kicked a 41-yarder to cut it to 14-6 in the second quarter. It was his 18th straight field goal, setting a team record.
The Eagles haven't won since beating the defending Super Bowl champion New York Giants to go 3-1, leaving fans and media to speculate about coach Andy Reid's job. Owner Jeffrey Lurie already has said that an 8-8 record would be "unacceptable" this year. The Eagles would have to finish 5-1 just to get there.
Fans known for their hostile behavior have become apathetic toward their beloved Eagles. The Linc was about one-third empty for pregame introductions and plenty of seats remained empty at the start. There were boos early when the Eagles fell behind, but they lacked the usual luster.
The Panthers are better than their record. They have lost six games by less than a touchdown, including a 2-point loss at Atlanta and a 1-point loss at Chicago.
The injury-depleted Eagles lost wide receiver DeSean Jackson (sternum) and defensive tackle Fletcher Cox (tail bone) in the first half.
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Online: http://pro32.ap.org/poll and http://twitter.com/APNFL
Carolina 30, Philadelphia 22
Carolina 14 0 7 9 30
Philadelphia 3 12 7 0 22
Phi • FG Henery 36, 11:12.
Car • Barnidge 24 pass from Newton (Gano kick), 6:12.
Car • LaFell 43 pass from Newton (Gano kick), 3:36.
Phi • FG Henery 41, 14:15.
Phi • Brown 65 run (pass failed), 10:56.
Phi • FG Henery 45, 3:20.
Car • Newton 1 run (Gano kick), 9:13.
Phi • Brown 5 run (Henery kick), 3:30.
Car • FG Gano 23, 12:40.
Car • Newton 2 run (kick failed), 4:40.
Attendance • 69,144.
First downs 24 18
Total Net Yards 398 311
Rushes-yards 35-109 26-204
Passing 289 107
Punt Returns 0-0 2-32
Kickoff Returns 5-114 4-110
Interceptions Ret. 0-0 0-0
Comp-Att-Int 18-28-0 16-21-0
Sacked-Yards Lost 2-17 1-12
Punts 5-37.6 2-41.0
Fumbles-Lost 0-0 4-3
Penalties-yards 6-101 5-30
Time of Possession 35:12 24:48
Rushing • Carolina, Newton 14-52, Stewart 8-27, D.Williams 11-21, LaFell 1-6, Tolbert 1-3. Philadelphia, Brown 19-178, Lewis 5-24, Jackson 1-2, Foles 1-0.
Passing • Carolina, Newton 18-28-0-306. Philadelphia, Foles 16-21-0-119.
Receiving • Carolina, Smith 4-60, Olsen 4-50, LaFell 3-74, Murphy 2-65, Tolbert 2-24, Stewart 2-9, Barnidge 1-24. Philadelphia, Maclin 5-55, Brown 4-11, Celek 2-19, D.Johnson 2-13, Jackson 1-9, Cooper 1-7, Havili 1-5.
Missed Field Goals • None.