Solomon Hill added 13 points, Brandon Ashley 11 and Kaleb Tarczewski 10 for Arizona. No USC player reached double figures in the Trojans' lowest-scoring game of the season. Jio Fontan scored nine.
USC dropped to 1-3 since Kevin O'Neill was fired and replaced by interim coach Bob Cantu. The other two losses were by one point to Oregon and 98-93 in overtime Thursday night at Arizona State.
This one was a blowout in a hurry.
The Wildcats, who fell behind UCLA 21-5 in Thursday night's 84-73 home loss to the Bruins, turned the tables on the Trojans.
No. 16 Oregon 81, Washington 76 • E.J. Singler scored 18 points and No. 16 Oregon stayed undefeated at home.
Arsalan Kazemi added 11 points and 11 rebounds, and Carlos Emory also scored 11 for the Ducks (18-2, 7-0 Pac-12).
Andrew Andrews scored 15, C.J. Wilcox added 14 points and Abdul Gaddy and Scott Suggs had 13 each for the Huskies (12-8, 4-3).