Troy Daniels had 23 points, Juvonte Reddic scored 21 and fifth-seeded VCU throttled 12th-seeded Akron 88-42 on Thursday night.
The Rams broke a margin-of-defeat record by a team seeded third or lower set by No. 3 Arizona in 1996, when it beat 14th-seeded Valparaiso by 39 points, according to STATS.
The previous mark by a fifth-seeded team against a 12th-seeded squad was set by Wyoming in a 35-point win over Howard in 1981 and matched by Tennessee against Long Beach State in 2007, according to STATS.
"It's a great accomplishment," Daniels said. "We'll take it, but we've got to get ready to play Saturday."
Michigan 71, South Dakota State 56 • Nate Wolters helped contain Trey Burke, so in the much-anticipated matchup of star point guards, South Dakota State more than held its own in Auburn Hills, Mich.
It was the rest of the Michigan lineup the Jackrabbits had trouble with.
Glenn Robinson III scored 21 points and Mitch McGary added 13 points and nine rebounds, helping fourth-seeded Michigan overcome a rough night for Burke in a second-round win over 13th-seeded South Dakota State on Thursday night.
"We were trying to make Glenn Robinson beat us," South Dakota State forward Jordan Dykstra said. "Unfortunately, he kind of did tonight."