"You take it in stride," he said Sunday. "I try not to ever get too low. I fight adversity as hard as I can fight it, not get too low. When good things happen, I don't really embrace it. I just say it's a lucky day."
The Cardinals (34-5) play fourth-seeded Michigan (31-7) on Monday night, with Louisville an 4-point favorite.
Pitino has come a long way from the brash coach who led Kentucky to the national title in 1996. A long way, even, from the coach whose buttoned-down reputation was left in tatters following an extortion case four years ago that exposed the messy details of his private life. He's learned humility late in the game, and he and his players are all the better for it.
"If I had one regret in life, it wouldn't be what you think," Pitino said. "It's that I wasn't more humble at an earlier age."
The comeuppance began in Boston.
Pitino was the hottest commodity in college coaching when he went to the Celtics, following that '96 title and another trip to the championship game the next year. But assembling a college team is different from doing it in the NBA, and Pitino was 102-146 in three-plus seasons. The most lasting memory of his tenure was not a playoff run, but a postgame rant in which he chastised Celtics fans, "Larry Bird is not walking through that door."
He returned to the college ranks, taking the Louisville job in the spring of 2001. Six months later, his brother-in-law and best friend died in the Sept. 11 attacks.
And in 2009, he was forced to admit he'd had a sexual encounter with a woman who later tried to extort millions from him.
"I can give you some years where it went the other way," Pitino said Sunday when someone asked if he was leading a charmed life.
But the pain and humiliation ultimately served a greater purpose.
"For the first time in my life, I thought about maybe packing it in and doing something else three years ago," Pitino said earlier in the tournament. "I said, 'You know what, I'm not going to do that. I'm going coach as long as I can coach, but I'm going to make one big change. We're going to work just as hard as we've ever worked, if not more, but we're going to have a blast doing it.'
"It's worked very well."