"I expect Aldon like today he'll be back to work and playing on Sunday," Harbaugh said. "I anticipate that, yes."
Harbaugh said that any potential discipline will likely come from the NFL.
"There will be consequences. There always is," Harbaugh said. "Good or bad, we all have consequences."
Smith, 23, posted $5,250 bail and was released from the Santa Clara County jail late Friday morning, just hours after he was taken into custody by police responding to a single-vehicle crash that involved his truck in San Jose, Santa Clara County Sheriff's Sgt. Kurtis Stenderup said.
The linebacker, who helped the 49ers get to the Super Bowl last season, has 37 sacks in 34 career games and was selected to his first Pro Bowl and named All Pro last year.
Smith won the team's MVP award last season as he set the Niners' franchise record with 19 ½ sacks. A first-round draft pick out of Missouri in 2011, Smith also set the team's rookie sack record with 14 that year.
Around the league
Ravens • Running back Ray Rice is listed as doubtful for Sunday's game against Houston. The Pro Bowler, who strained his left hip flexor during a win over the Cleveland Browns last week, missed his third consecutive day of practice.
Seahawks • Seattle placed left tackle Russell Okung on injured reserve with a designation to return after suffering a torn ligament in his toe against San Francisco.
Titans • Tennessee's Jackie Battle was fined $21,000, becoming the first running back docked for violating a new rule in effect this season against lowering the crown of his helmet into an opponent.
Cardinals • Receiver Larry Fitzgerald (hamstring) and running back Rashard Mendenhall (toe) practiced on a limited basis Friday and were listed as questionable for Sunday's game at New Orleans. It was the first time either player practiced this week.
Lions • Running back Reggie Bush (knee) and defensive tackle Nick Fairley (shoulder) are listed as questionable for Sunday's game at Washington. Both were limited in practice.
Week 3 schedule
Kansas City 26, Philadelphia 16
San Diego at Tennessee, 11 a.m.
Arizona at New Orleans, 11 a.m.
St. Louis at Dallas, 11 a.m.
Cleveland at Minnesota, 11 a.m.
Houston at Baltimore, 11 a.m., Ch. 2
N.Y. Giants at Carolina, 11 a.m.
Detroit at Washington, 11 a.m.
Tampa Bay at New England, 11 a.m.
Green Bay at Cincinnati, 11 a.m., Ch. 13
Atlanta at Miami, 2:05 p.m.
Indianapolis at San Francisco, 2:25 p.m., Ch. 2
Jacksonville at Seattle, 2:25 p.m.
Buffalo at N.Y. Jets, 2:25 p.m.
Chicago at Pittsburgh, 6:30 p.m., Ch. 5
Oakland at Denver, 6:40 p.m., ESPN