Bradford's injury is a devastating blow to the St. Louis Rams, who will turn to backup quarterback Kellen Clemens.
Wayne's injury seriously dampened the Indianapolis Colts' spirit after a big win over Peyton Manning.
"I have great respect for what he does on the field, but just as genuine concern for him as a person," Clemens said of Bradford, who was hurt when he was pushed by Carolina's Mike Mitchell late in the fourth quarter of a loss to the Panthers.
Bradford tore his left ACL, which coach Jeff Fisher said was already in a brace. The former No. 1 overall pick had 14 touchdown passes and just four interceptions in his fourth season.
Wayne tore his right ACL in the fourth quarter of a victory over Denver. The soon-to-be 35-year-old wide receiver had played in 189 consecutive games. Wayne led his team with 38 catches and 503 yards this season. In 13 seasons, all with the Colts, he has 1,006 receptions, 13,506 yards and 80 TD catches.
"Looking back at it again today, there was really no one within 30 yards of him," quarterback Andrew Luck said. "He probably would have scored if I actually give him a decent ball. I feel somewhat responsible for the whole thing. I think I feel sick to my stomach about it a little bit."
Titans owner Adams dead at 90
Titans owner Bud Adams, who helped found the American Football League and whose battles for players helped lead to the merger with the NFL, has died. He was 90.
The team announced Monday that Adams had died, saying he "passed away peacefully from natural causes."
The son of a prominent oil executive, Adams built his own energy fortune and founded the Houston Oilers. He moved the team to Tennessee in 1997 when he couldn't get the new stadium he wanted in Houston. The franchise, renamed the Titans, in 2000 reached the Super Bowl that Adams had spent more than three decades pursuing.
Adams' 409 wins were the most of any current NFL owner.
"I consider Bud one of the founders of the game of professional football because of his role in helping to create the American Football League," Dallas owner Jerry Jones said in a statement.
Around the league
Bears • Quarterback Jay Cutler will miss at least the next four weeks after tearing a muscle in his groin during a Sunday's loss to Washington. Pro Bowl linebacker Lance Briggs will be out for around six weeks after sustaining a small fracture in his left shoulder.
Packers • Coach Mike McCarthy says tight end Jermichael Finley suffered a significant neck injury in Sunday's win over the Browns and needs more tests to determine the severity. But McCarthy said Finley, who has been hospitalized, is upbeat and "performing daily activities."
Texans • Pro Bowl linebacker Brian Cushing is out for the season with a left knee injury that will require surgery. Cushing, who tore his left ACL last season, was injured in the third quarter of a loss at Kansas City.
Seahawks • Wide receiver Percy Harvin is returning to practice after missing the first seven weeks of the regular season following hip surgery. Harvin has been on the physically unable to perform list all season after surgery to repair the labrum in his hip in early August.
Dolphins • Miami acquired tackle Bryant McKinnie from Baltimore for a conditional late-round draft pick. The 34-year-old McKinnie will likely compete for playing time with right tackle Tyson Clabo, even though McKinnie lost his starting job two weeks ago.
Washington • Free safety Brandon Meriweather's dangerous habit of leading with his helmet will cost him two games, the latest sanction from a league determined to make the game safer by discouraging blows to the head. He was flagged twice for hits on defenseless receivers in Sunday's win over Chicago.