The Broncos said he had a lower leg injury and removed him from the game.
During the night, Moore called the team's athletic trainer because he was still experiencing pain and swelling and was told to see a doctor, who determined he needed what's called a fasciotomy.
That's where a surgeon cuts open the skin and fascia covering the affected compartment, which are groupings of muscles, nerves and blood vessels.
Compartment syndrome develops when swelling or bleeding occurs within a compartment, which the American Academy of Orthopaedic Surgeons says can be caused by athletic exertion. It's rarely seen in football players, however.
Moore has had a resurgent season after being the goat in Denver's double-overtime loss to Baltimore in the playoffs last year. He allowed Jacoby Jones' 70-yard touchdown catch in the final minute of regulation in that game when he went for the interception instead of the tackle and mistimed his leap at the 20-yard line.
This year, he has 44 tackles and two interceptions.
Colts linebacker Erik Walden's head-butt and Buccaneers safety Dashon Goldson's helmet-to-helmet hit have earned one-game suspensions from the NFL.
Walden pulled off the helmet of Titans tight end Delanie Walker, then slammed his own helmet into Walker's head during a game Thursday.
Goldson was penalized for unnecessary roughness for his hit on a defenseless receiver, Roddy White, against Atlanta on Sunday. It was Goldson's third such violation this season.
Around the league
Lions • Coach Jim Schwartz is standing by his decision to call a fake field goal in the fourth quarter at Pittsburgh. "We got the look that we wanted, we thought it was there, we didn't execute it great," Schwartz said Monday. "If we think there's something there special teams-wise, next week, not going to be afraid to call it." The Lions were up by four early in the final quarter against the Steelers on Sunday, but their fake deep in Pittsburgh territory didn't work. Detroit collapsed after that, allowing two TDs and losing 37-27.
Texans • Coach Gary Kubiak is sticking with Case Keenum as his starter despite pulling the quarterback for Matt Schaub late in Houston's loss to Oakland on Sunday.