After a hearing with the prosecutor in September, Di Luca did not deny doping, saying that the case "doesn't change much" for his fans.
Still, Di Luca could appeal to the Switzerland-based Court of Arbitration for Sport.
Last year, Armstrong was banned for life by the United States Anti-Doping Association and stripped of his seven Tour de France titles for doping.
The Vini Fantini-Selle Italia squad fired Di Luca immediately after his latest positive test was announced with the Giro nearly finished.
In 2009, Di Luca was given a two-year ban after testing positive during the Giro for CERA, an advanced form of EPO. That ban was subsequently reduced by nine months after he collaborated with Italian anti-doping authorities.
And a short time after winning the 2007 Giro, Di Luca was banned for three months for frequent visits to Carlo Santuccione, a physician at the center of a four-year doping investigation titled Oil for Drugs.
Di Luca was stripped of his second-place finish and two stage wins in the 2009 Giro, which was won by Russian rider Denis Menchov.
Seemingly headed for retirement just a few months before this year's Giro, Di Luca signed with Vini Fantini in April a week before the race began. He fared well in several stages of the Italian classic, with four top-10 finishes.
His results from this year's Giro will now be stripped.
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