The Bees had a chance to take control in the opening three innings, when they bunched eight hits. But Salt Lake scored only twice and left six runners on base, including three in scoring position.
That's all Las Vegas needed.
With the Bees leading 2-1 in the fourth, Allan Dykstra, Zach Lutz, Taylor Teagarden and Brandon Allen blasted home runs in consecutive at-bats.
Dykstra's two-run blast started the explosion. Lutz, Teagarden and Allen followed with solo shots against Salt Lake starter Jose Alvarez.
"He was going well," Bees manager Keith Johnson said. "But after the first guy hit the home run, he tried to make a little better pitch. Then to every hitter he tried to make better pitches, better pitches, better pitches. ... Sometimes that happens."
Leading 6-2, Las Vegas extended its lead in the fifth on Kirk Nieuwenhuis' leadoff homer meaning Alvarez tied a franchise record for most home runs allowed in a game.
Incredibly, the 51s' five homers came during only one trip through the batting order.
The Bees stayed close in the bottom of the fifth, when John Hester's RBI single and Roberto Lopez' one-out sacrifice fly made it 7-4.
Las Vegas quickly countered, however, with two more runs in the sixth.
With two out, Lutz worked the count to 3-2 against Bees' relief pitcher Michael Brady before dumping a short fly into short right. Eric Campbell and Brown raced home on the weakly hit single to restore the 51s' five-run advantage and propel them to an easy win.
"We have to stay away from the big inning," Johnson said. "That's been our nemesis. But our guys will figure it out. There's still a lot of ball left to play. ... We're going to go out there and compete. That's what I care about."
For the Bees, it was their fourth straight loss.
While Las Vegas dominated this game after its four straight homers, however, the other three were winnable.
Two came after massive late-game collapses by the bullpen. The other involved by a base-running error in the bottom of the ninth that eventually prevented the Bees from trying the score.
Storylines 51s 16, Bees 4
R Brennan Boesch goes 3 for 3 with a double to lead the Bees.