Two of the cases one in Paktia province in 2010 and another in Wardak province from November 2012 to February 2013 involved "abundant and compelling evidence of war crimes," the report said.
"None of the cases that we looked into involving more than 140 civilian deaths were prosecuted by the U.S. military," Richard Bennett, Amnesty International's Asia Pacific Director, said in a statement. "Evidence of possible war crimes and unlawful killings has seemingly been ignored."
In a statement, NATO said it reviewed Amnesty's report, but did not comment on the specific incidents cited. It said it investigates all credible reports of civilian deaths in its operations when circumstances allow.
"Coalition leadership also ensures that (NATO) takes steps to minimize the risk to civilians during military operations and works with our Afghan partners to do the same," NATO said.
NATO said civilian casualties from its operations are down 77 percent in the past year.
Afghan civilians increasingly find themselves under fire as the 2001 U.S.-led war draws to a close, as Afghan forces take the lead in operations targeting the Taliban. The civilian death toll in the war in Afghanistan rose 17 percent for the first half of this year, the United Nations reported in July. The U.N. said 1,564 civilians were killed from January through June, compared with 1,342 in the first six months of 2013.
However, the U.N. found that Taliban fighters and other militants have been responsible for the majority of the civilian killings. Insurgents were responsible for 74 percent of the casualties, the U.N. said, while pro-government forces were responsible for 9 percent, government forces 8 percent and foreign troops just 1 percent. The rest could not be attributed to any group.
In its report, Amnesty International said U.S. and NATO forces have made significant strides toward preventing civilian casualties, though lingering questions over the 10 incidents it cited casts a pall over their efforts.
"The legacy of international military operations is seriously tainted, however, when military forces leave behind families whose efforts to seek justice have been ignored," the report said.
Santana reported from Islamabad.