Eli Lilly • Drugmaker will discuss study results with regulators and plan next steps.
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Indianapolis • A possible Alzheimer's disease treatment from drugmaker Eli Lilly missed the main goals of two late-stage studies, but the treatment showed some potential for slowing memory decline in patients with mild cases of the mind-robbing condition.
Shares of the Lilly climbed Friday after the Indianapolis company announced what could be a step toward a long-awaited breakthrough in the fight against a disease that has no cure and ultimately proves fatal. But doctors and Lilly officials cautioned against overreacting to the study's initial results.
Lilly said Friday that its treatment, solanezumab, failed to slow cognitive decline, which involves a person's ability to remember things, in two late-stage studies of about 1,000 patients each. But when data from the trials were combined, scientists saw a statistically significant slowing of the rate of cognitive decline in that bigger population.
They also saw a statistically significant result when they examined a subgroup of patients with mild cases of Alzheimer's disease. The studies focused on patients with mild to moderate Alzheimer's cases.
The studies fell short of their main goals, and that means the drug "isn't going to the (Food and Drug Administration) tomorrow to be approved for sale," said William H Thies, chief medical and scientific officer for the Alzheimer's Association, which was not involved in Lilly's research. Still, he said the statistical significance of the combined results is important.
"If that can be replicated, that is a major finding," he said. "It's the first time we've been able to change the course of Alzheimer's disease or any part of Alzheimer's disease in people."
Lilly said it will discuss the results with regulators and plan the next steps. Full results from the studies will be presented at two scientific conferences in October, the company said.
It's unclear how the Food and Drug Administration will view the results, given that the drug missed its main goals.
If you look through "rose-colored glasses" at the results, there may be a sign of potential benefit on cognitive tests, but it is not clear whether that is enough to make a real difference clinically in how patients do, said Dr. Ronald Petersen, director of the Mayo Clinic's Alzheimer's Disease Research Center.
The key will be details the company will present later on brain imaging and other tests, he said. If those show that the drug is helping clear plaque, "it might mean that the drug is doing what it's supposed to be doing, but we're just attacking the disease too late," said Petersen, who heads a safety monitoring panel for two companies working on a different Alzheimer's treatment.
It's up to the FDA to decide how much faith to put in secondary analyses or results in subgroups, he added.
"The danger would be an over-interpretation of a small finding or a subtle effect," Petersen said.
About 35 million people worldwide have dementia, a term for brain disorders that affect memory, judgment and other mental functions. Alzheimer's is the most common type. In the United States, more than 5 million people have Alzheimer's, which is the country's sixth-leading cause of death.
Many Alzheimer's patients typically live four to eight years after diagnosis, as the disease gradually erodes their memory and ability to think or perform simple tasks. Current Alzheimer's treatments only temporarily ease symptoms such as memory loss, confusion and agitation. They don't slow, stop or reverse mental decline.
Drugmakers have tried and failed for years to develop successful treatments for the disease, and patients and doctors are anxious for any signs of promise. Analysts have said an approved treatment that slows the disease's progression could be worth billions of dollars in sales.
Earlier this month, Pfizer Inc. and Johnson & Johnson said they would end development of an intravenous version of their potential Alzheimer's treatment, bapineuzumab, after two late-stage studies showed it worked no better than a placebo in patients with mild-to-moderate cases.
Lilly officials cautioned Friday that their study did not show that solanezumab slowed the progression of Alzheimer's. It showed signs of slowing cognitive decline, one of many ways the disease impacts a person's mind. Even so, they were encouraged.
Solanezumab binds to beta-amyloid protein, which scientists believe is a key component to sticky plaque that basically gums up the brain of a patient with Alzheimer's disease. The drug is designed to bind to the protein and help the body remove it from the brain before it can form that plaque. Lilly said that while the individual trials missed their main goals, the combined results showed there may be some validity to this approach.
"We really think this idea of attacking amyloid plaques is a valid hypothesis, that's important news," said Dave Ricks, president of Lilly Bio-Medicines.
But Dr. Sam Gandy, head of Alzheimer's disease research at Mount Sinai School of Medicine in New York, said Lilly's statement on the results "is very tentative."
"I believe in the notion that an amyloid-lowering agent like solanezumab will eventually work in early disease or pre-symptomatically, but whether these data provide compelling evidence that solanezumab has 'cleared the bar' just cannot be concluded" until full results are presented, Gandy wrote in an email.
Bernstein research analyst Dr. Tim Anderson said in a research note he guesses that more studies will have to be done on the Lilly drug before it is submitted for approval.
Baxter International Inc. also reported some encouraging results in July from its potential Alzheimer's treatment, Gammagard. The company said a tiny study indicated Gammagard might help stabilize Alzheimer's for up to three years. Four patients who got the highest dose of Gammagard for three years showed no decline on memory and cognition tests, but a dozen others on different doses or shorter treatment times didn't fare as well.
That study was too small to prove the treatment works, but a more rigorous one involving 400 patients will end late this year, with results expected by early next year.
Lilly shares climbed 2.4 percent, or $1.02, to $43.42 Friday, while broader trading indexes fell slightly. Anderson said the drugmaker's results would be viewed positively because expectations for the drug were low.