NFL: 49ers set franchise yards record, beat Bills 45-3

San Francisco • Alex Smith threw for a season-high 303 yards and three touchdowns, Frank Gore ran for 106 yards and a score, and the San Francisco 49ers amassed a franchise-record 621 yards in blowing by the Buffalo Bills 45-3 on Sunday.

Michael Crabtree and Vernon Davis each eclipsed 100 yards receiving to back Smith, who threw TD passes of 43, 28 and 10 yards and surpassed 300 yards passing for only the third time in his career.

Rian Lindell kicked a 31-yard field goal in the first quarter before San Francisco scored the final 42 points to hand Buffalo (2-3) its second straight embarrassing loss.

Ryan Fitzpatrick threw for 126 yards and an interception, and the Bills rushed for only 89 yards, most with the game well out of hand once again. —

Bills-49ers Stats

Buffalo 0 3 0 0 — 3

San Francisco 3 14 7 21 — 45

First Quarter

SF • FG Akers 19, 7:25.

Second Quarter

Buf • FG Lindell 31, 10:46.

SF • K.Williams 43 pass from Ale.Smith (Akers kick), 9:54.

SF • Crabtree 28 pass from Ale.Smith (Akers kick), :24.

Third Quarter

SF • Gore 1 run (Akers kick), 9:06.

Fourth Quarter

SF • Manningham 10 pass from Ale.Smith (Akers kick), 14:12.

SF • Kaepernick 16 run (Akers kick), 9:55.

SF • Dixon 3 run (Akers kick), 1:11.

Attendance • 69,732.

Buf SF

First downs 10 29

Total Net Yards 204 621

Rushes-yards 19-89 38-311

Passing 115 310

Punt Returns 1-28 3-19

Kickoff Returns 2-87 2-45

Interceptions Ret. 0-0 1-4

Comp-Att-Int 16-26-1 19-25-0

Sacked-Yards Lost 1-11 0-0

Punts 6-47.7 2-56.0

Fumbles-Lost 1-1 1-1

Penalties-yards 5-30 7-53

Time of Possession 23:43 36:17

Individual Statistics

Rushing • Buffalo, B.Smith 1-35, F.Jackson 9-29, Spiller 7-24, Fitzpatrick 2-1. San Francisco, Gore 14-106, Hunter 11-81, Ale.Smith 3-49, Kaepernick 4-39, Dixon 4-21, Miller 1-9, K.Williams 1-6.

Passing • Buffalo, Fitzpatrick 16-26-1-126. San Francisco, Ale.Smith 18-24-0-303, Kaepernick 1-1-0-7.

Receiving • Buffalo, St.Johnson 6-39, Chandler 4-40, Graham 2-28, Jones 2-13, F.Jackson 1-5, B.Smith 1-1. San Francisco, Crabtree 6-113, V.Davis 5-106, Manningham 4-26, K.Williams 2-50, Moss 1-11, Celek 1-4.

Missed Field Goals • None.