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Gaza City, Gaza Strip • Unrest that erupted several weeks ago at Jerusalem's most sensitive holy site spread Friday to Gaza in the form of deadly border clashes with Palestinian protesters as Israeli security forces struggled to contain a wave of Palestinian stabbing attacks against civilians and soldiers.

For the first time since the current violence began, clashes broke out along the Gaza border after Palestinians in the territory ruled by the Islamic militant group Hamas rolled burning tires and threw rocks at Israeli troops on the frontier. Six Palestinians were killed and a dozen were wounded, the Palestinian Health Ministry said.

The Israeli military said "More than a thousand rioters infiltrated the buffer zone engaging the forces at the security fence. Rioters reached the security fence — hurled a grenade, rocks and rolled burning tires at Israeli forces ... threatening to breach the fence and storm the adjacent communities." It said troops fired warning shots and then fired at main instigators to prevent their advance.

Recent days have seen a series of attacks by young Palestinians wielding household items like kitchen knives, screwdrivers and even a vegetable peeler.

The youths had no known links to armed groups who have targeted Israeli soldiers and civilians at random, complicating security efforts.

The violence, including the first apparent revenge attack by an Israeli, raised fears of the unrest spiraling further out of control.

The unpredictability and brutality of the assaults, coupled with the young age of some of the attackers, have shocked Israelis and raised fears a new Palestinian intifada — or uprising — could be underway.

In Jerusalem, a Palestinian stabbed and wounded a 14-year-old Israeli with a vegetable peeler Friday before being arrested. In another attack near the entrance of Kiryat Arba, a West Bank settlement, a Palestinian was shot dead by a police officer after he attacked him with a knife and tried to seize his weapon, police said.

In northern Israel, a 29-year-old Arab-Israeli woman was shot and wounded while trying to stab people at a bus station in the town of Afula.

Gaza-based Hamas leader Ismail Haniyeh applauded the recent Palestinian stabbing attacks across Israel during a speech at Friday prayers, labeling it as an intifada.

Israeli officials have said the violence is not on that scale for now, but rather is of the kind unleashed periodically over the decades.

Prime Minister Benjamin Netanyahu has called it a "terror wave."

He and Palestinian Prime Minister Mahmoud Abbas have tried to lower tensions in recent days but both appear unable to contain the unrest.

Arabs make up some 20 percent of Israel's population. They enjoy full citizenship rights but have long complained of discrimination in housing, jobs and other areas of society. They often identify with Palestinian nationalism.

The latest unrest began about three weeks ago, when Palestinians repeatedly barricaded themselves inside the Al-Aqsa Mosque compound in Jerusalem's Old City, hurling stones, firebombs and fireworks at police.

It was fueled by Palestinian allegations that Israel plans to change the delicate arrangement at the hilltop compound, sacred to both Muslims and Jews.

Israel has adamantly denied the allegations and accused Palestinian leaders of inciting the violence and spreading lies over the shrines in east Jerusalem. Abbas gave a hard-line speech at the U.N. last month, saying Israelis desecrate the holy site with their "dirty feet."

Non-Muslim visitors are only allowed to enter the site at specific hours and are banned by police from praying there. Many Muslims view these visits as a provocation and accuse Jewish extremists of plotting to take over the site. Israel has promised to ensure the delicate arrangement at the site and insists it will not allow the status quo to be changed.