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Gilze-Rijen Air Base, Netherlands • The missile shot skyward from war-ravaged eastern Ukraine. With deadly accuracy more than 6 miles up, it detonated just in front of the Malaysia Airlines jetliner, sending hundreds of jagged steel shards ripping through its aluminum skin at up to 5,600 mph and shearing the cockpit from the rest of the plane.

The two pilots and purser in the cockpit died instantly, and the Boeing 777 disintegrated and fell to Earth, killing the rest of the 298 men, women and children aboard Flight 17 on July 17, 2014, Dutch investigators said Tuesday in a long-awaited report.

Some of the victims may have been conscious for 60 to 90 seconds, the Dutch Safety Board said, but they probably were not fully aware of what was happening in the oxygen-starved, freezing chaos. The tornadolike airflow surging through the doomed jet as it came apart was powerful enough to tear off people's clothes and leave naked corpses amid the fields of sunflowers.

The 15-month Dutch investigation blamed a Soviet-made surface-to-air Buk missile for downing the Amsterdam to Kuala Lumpur flight, but it did not explicitly say who had fired it. It identified an area of 120 square miles where it said the launch must have taken place, and all of the land was in the hands of pro-Russian separatists fighting Ukrainian forces at the time of the disaster, according to daily maps of fighting released by the Ukrainian National Security Council.

The Dutch Safety Board also found that the tragedy wouldn't have happened if the airspace of eastern Ukraine had been closed to passenger planes as fighting raged below.

"Our investigation showed that all parties regarded the conflict in eastern part of Ukraine from a military perspective. Nobody gave any thought of a possible threat to civil aviation," Safety Board Chairman Tjibbe Joustra said. He spoke in front of the partially reassembled red, white and blue Malaysian jetliner, much of the left side of its mangled fuselage front riddled with shrapnel holes.

Russian officials were prompt to dismiss the Dutch report. Deputy Foreign Minister Sergei Ryabkov calling it an obvious "attempt to make a biased conclusion, in essence to carry out a political order."

Earlier Tuesday, the Buk's manufacturer presented its own report trying to clear the separatists, and Russia itself, of any involvement.

The Russian state-controlled consortium Almaz-Antey said it conducted experiments, including one in which a Buk missile was detonated near the nose of an airplane similar to a 777, and it contended they contradicted the conclusion that a Buk missile of the kind used by the Russians destroyed Flight 17. Almaz-Antey had earlier suggested that it could have been a model of Buk that is no longer in service with the Russian military but is part of Ukraine's arsenal.

It said the experiments also rebutted claims the missile was fired from Snizhne, a village that was under rebel control. An Associated Press reporter saw a Buk missile system in that vicinity on the same day.

Despite the moves by Moscow, Prime Minister Mark Rutte of the Netherlands called on Russia to fully cooperate with a separate criminal investigation that Dutch prosecutors are conducting into the downing of the plane, in which 196 Dutch nationals died.

In a statement, the Dutch-led Joint Investigation Team said it has already identified "persons of interest" in the probe, but said it is "not easy" to find witnesses, especially ones willing to make a statement. They said their probe will stretch into 2016.

At U.N. headquarters, Ukrainian Foreign Minister Pavlo Klimkin defended his country's decision not to close its airspace, saying no one at the time was aware of the possibility that Russia had brought highly sophisticated anti-aircraft missiles into Ukraine.

Klimkin also praised the Dutch report as "fully unbiased and transparent," and said what now is needed is for a criminal investigation to reveal the chain of command and bring those responsible to justice.

Malaysia's Prime Minister Najib Razak also said the world "must move forward toward ensuring that those responsible are held accountable for this murderous act." There were 43 Malaysians aboard, the second-highest total.

Dutch investigators said the missile detonated less than 3.3 feet from the plane, to the left side of the cockpit, sending the shrapnel into the plane at speeds of up to 5,600 mph).

Joustra said missile fragments found in the cockpit crew's bodies, as well as paint traces, helped investigators to identify the Buk. Some of the pieces of metal, he said, were shaped like cubes or "bow ties" — a detail weapons experts called extremely significant.

"The overall picture is conclusive — a 9M38M1 surface-to-air missile from a Buk operated from rebel-held territory in east Ukraine was responsible for the shooting down of MH17," said Nick de Larrinaga, Europe editor for IHS Jane's Defense Weekly.