His 6-3, 6-3, 4-6, 6-2 loss to 88th-ranked Nicolas Mahut at the French Open dropped Roddick's record to 7-10 this season, 0-4 on clay. Of the seven previous major title winners in action on Day 1 in Paris, including Venus Williams in her first Grand Slam match since revealing in August she was diagnosed with an autoimmune disease, only Roddick was beaten.
"Wasn't playing really well. I move just horrendously out here. My first step is just so bad on this stuff," Roddick said. "I feel like I'm always shuffling or hopping or not stopping or something."
Like Roddick, and for much the same reasons, Williams is not nearly as comfortable on clay as faster surfaces.
She's also dealing with the difficult process of learning to live with Sjogren's syndrome, a condition that can cause fatigue and joint pain. But the 31-year-old Williams, a seven-time major champion, overcame a slow start Sunday to beat 19-year-old Paula Ormaechea of Argentina 4-6, 6-1, 6-3.
"A lot of it, I have to figure it out. It's physical and emotional and all kinds of different things. Mental," Williams said of her medical condition. "It's a big accomplishment for me to be here right now."
She looked glum on court, not even smiling after most of her 41 winners (Ormaechea only had 15). But she laughed frequently during her news conference, such as when she talked about what she's been going through as "definitely an adventure and journey; it's life happening."
The other past major champions who won Sunday were Juan Martin del Potro, Juan Carlos Ferrero, Sam Stosur, Ana Ivanovic and Svetlana Kuznetsova. Monday's schedule includes Novak Djokovic, Roger Federer, Victoria Azarenka and Li Na.
At a glance
Men's seeded winners • No. 5 Jo-Wilfried Tsonga, No. 9 Juan Martin Del Potro, No. 14 Fernando Verdasco, No. 18 Stanislas Wawrinka, No. 21 Marin Cilic.
Men's seeded losers • No. 26 Andy Roddick, No. 30 Jurgen Melzer.
Women's seeded winners • No. 6 Sam Stosur, No. 10 Angelique Kerber, No. 13 Ana Ivanovic, No. 20 Lucie Safarova, No. 21 Sara Errani, No. 26 Svetlana Kuznetsova.
Women's seeded losers • None.