Russ Smith added 19 points and Luke Hancock made three 3-pointers and finished with 13 points as the Cardinals (22-5, 10-4) won their third in a row.
Against Seton Hall, Louisville wanted to firm up its game ahead of an important stretch run including next week's showdown at No. 8 Syracuse. The Cardinals succeeded on just about every count, forcing 21 turnovers including 12 steals and shooting 26 of 57 (45.6 percent).
Aaron Cosby scored 14 second-half points for 17 to lead Seton Hall (13-15, 2-13), which dropped its ninth straight.
Eugene Teague added 16 points, Brian Oliver 12 and Fuquan Edwin 11 for the Pirates, who shot 23 of 52 (44 percent).