The prospect of such interviews that may ensue under such a plea alarmed defense attorneys, who filed documents opposing the technique.
Holmes, 25, is scheduled to enter a plea Tuesday to multiple counts of murder and attempted murder. He is charged with killing 12 people and injuring 70 at a midnight showing of "The Dark Knight Rises" in the Denver suburb of Aurora.
If Holmes pleads not guilty by reason of insanity, he would be examined by doctors at the state mental hospital.
In an advisory that Holmes would have to sign if he enters an insanity plea, Sylvester didn't specify what type of drugs would be used but said the examination could include "medically appropriate" ones.
Sylvester said Holmes also could be given a polygraph examination as part of the evaluation.
After reading a draft of the advisory, Holmes' lawyers objected, saying a narcoanalytic interview and a polygraph would violate their client's rights.
In the final version of the advisory, Sylvester said he had incorporated some suggestions from the defense and the prosecution, but he did not address the defense objections to a narcoanalytic interview and polygraph.
Karen Steinhauser, a former prosecutor who is a law professor at the University of Denver and a defense attorney, said she could not find any case law about use of the narcoanalytic interview.
"It comes up so rarely," she said, adding she knows nothing about it.
She noted the technique is clearly allowed by Colorado law.
Associated Press writer Nicholas Riccardi contributed to this report