These two teams have had the best rivalry in the sport over the past few years, and Sunday's meeting might be the final chapter with Notre Dame heading to the Atlantic Coast Conference next season.
Two years ago, the Huskies had won the first three meetings before Notre Dame shocked them in the national semifinals. That started an unprecedented run in which the Irish have taken over the rivalry, winning seven of the last eight meetings.
This year, the two schools played three thrilling games, with Notre Dame coming out on top by one point, two points and in triple overtime.
Cal vs. Louisville
Louisville has really relished being the underdog. So coach Jeff Walz doesn't want to hear about how the Cardinals have that team-of-destiny air about them heading into the women's Final Four.
Yet, is there any other way to see Louisville after it derailed AP Player of the Year Brittney Griner and defending national champion Baylor, and then upset Tennessee the most storied program in the sport?
Surely they couldn't be the underdogs against Final Four newcomer California (32-3) in Sunday's national semifinals. Don't tell that to Walz.
"No one expects us to win now," Walz insisted.
While destiny may be on Louisville's side, history is not. No team seeded worse than fourth has ever won a national semifinal game.
Women's Final Four
P Louisville (28-8) vs. California (32-3), 4:30 p.m.
• Notre Dame (35-1) vs. Connecticut (33-4), 6:30 p.m.
TV • Both games on ESPN