Smith, the rookie from West Virginia who is Sanchez's main competition at quarterback this preseason, exited early in the third quarter after appearing to hurt his right ankle.
Sanchez bounced back to throw a touchdown pass before leaving the game after three offensive series. He went 10 of 13 for 125 yards. Smith was 6 of 7 for 47 yards but did not lead any scoring drives.
Detroit's Matthew Stafford played two series, going 3 of 8 for 58 yards and leading the Lions to a field goal. All three of his completions went to Calvin Johnson.
Ansah grew up in Ghana, playing soccer and basketball. He put on football pads for the first time three years ago, and now the Lions hope he'll become a big part of their defense. Detroit took the 6-foot-5 defensive end from BYU with the No. 5 pick in this year's draft.
Ansah was able to get his hands up quickly when he intercepted Sanchez's screen pass, and his return to the end zone made it 7-0.
Pittsburgh Steelers receiver Plaxico Burress will have surgery on Monday to repair an injury in his right shoulder and is out indefinitely. Coach Mike Tomlin called the damage to Burress' shoulder "significant" but declined to specify the exact nature of the injury.
The 35-year-old Burress landed awkwardly while trying to haul in a pass over cornerback Da'Mon Cromartie-Smith near the end of Thursday's practice at Saint Vincent College.
Burress signed with Pittsburgh last November and caught three passes in limited action. He was battling Jerricho Cotchery, David Gilreath and rookies Markus Wheaton and Justin Brown for a spot behind starters Antonio Brown and Emmanuel Sanders.
The Steelers open the preseason Saturday night against the New York Giants.
Around the league
Browns • Starting right guard Shawn Lauvao is undergoing arthroscopic ankle surgery and will not be ready for the start of the regular season.
Rams • Coach Jeff Fisher says right tackle Rodger Saffold may miss up to two weeks after dislocating his left shoulder in the preseason opener Thursday against Cleveland. Saffold made the switch to the right side of the line this season after the Rams signed four-time Pro Bowler Jake Long from Miami in the offseason to play left tackle.
O Friday's games
• Detroit 26, N.Y. Jets 17
• Miami 27, Jacksonville 3
• New England 31,Philadelphia 22
• Houston 27, Minnesota 13
• Arizona 17, Green Bay 0
• Carolina 24, Chicago 17
• New Orleans 17, Kansas City 13
• Dallas at Oakland, late
• N.Y. Giants at Pittsburgh, 5:30 p.m., NFL Network