Eric Gryba and Jared Cowen also scored for the Senators, who had three goals on eight shots against Jimmy Howard before the Detroit goalie was taken out in the first period.
Craig Anderson made 31 saves for Ottawa.
Todd Bertuzzi scored for the Red Wings.
Spezza has seven goals on the season, trailing only Washington's Alex Ovechkin, who leads the NHL with nine. Ryan has scored six.
Alfredsson is Ottawa's career leader in games (1,178), goals (426), assists (682) and points (1,108), but he had a quiet game Wednesday, along with the rest of the Red Wings. Alfredsson had two shots and was called for a third-period tripping minor.
BRUINS 5, SABRES 2
BUFFALO, N.Y. • Milan Lucic had two goals and an assist, and Torey Krug also scored twice to help Boston beat reeling Buffalo.
Dougie Hamilton also scored for Boston. The Bruins are 6-2 overall and have won their first four road games for the first time since 2010.
Nikita Zadorov and Cody Hodgson scored for Buffalo. At 1-9-1, the Sabres are off to their worst start in franchise history. They are winless in their first seven home games.
By the time Krug netted the second of his two third-period goals, the fans launched into what have become regular "Fire Darcy! Fire Darcy!" chants in reference to Sabres general manager Darcy Regier.