"When it's snowing like this, you have to go out there and do it like it wasn't snowing," said Holcomb, who won also won gold in Friday's two-man bobsled competition. "We knew we could step it up and go harder and go faster.
"It's the first time I've swept here in a couple of years, so it's nice to come home and show that my home track is still my track."
Holcomb, Curtis Tomasevicz, Steven Langton and Christopher Fogt, who is from Alpine, turned in a second run of 47.40 seconds, with a 4.78 push that nearly set a track record. Germany's Maximillian Arndt was second and Russia's Alexander Kasjanov was third.
The three teams were in a dead heat after one run, partly because of Holcomb's mistake.
"I was frustrated," the Park City native said. "I made a huge mistake, and it's frustrating when you nail the track except for one turn you haven't had trouble with in a while."
Holcomb, the defending Olympic champion and favorite for gold in the Sochi games, also swept the two men's events in Calgary last weekend.
The American women made history earlier in the day when they swept the medals for the first time.
Elana Meyers and Aja Evans won their second gold of the weekend with a 1:38.61 finish and moved to the top of the World Cup standings.
The other two American drivers Jamie Greubel and Jazmine Fenlator tied for second as both teamed with a different brakeman than Friday. Greubel rode with Lolo Jones for the first time; Jazmine Fenlator rode with Lauryn Williams.
"It felt pretty sweet to do it yesterday, so to come out and do it again, I can't even put it into words," Meyers said. "We had to go off the line as soon as possible so the grooves didn't fill up with the snow. I'm coming through curve one and I see all kinds of snow in there, and I was like, 'This is nice.'"
Jones said the juggling of lineups has tested their nerves a bit.
"It gives us confidence, but at the same time it keeps us on edge," Jones said. "Normally we know [who we ride with] at the beginning of the week, but it depended on the first race [Friday]."
Defending World Cup and Olympic champion Kaillie Humphries of Canada finished seventh.
World Cup bobsled
• Steven Holcomb won his fourth World Cup gold medal of the season with the fastest run of the day in the second race Saturday.
• Holcomb, a Park City native, was tied with Germany's Maximillian Arndt and Russia's Alexander Kasjanov after one race.
• American women finished 1-2-2 in four-person bobsled, led by Elana Meyers and Aja Evans, who won their second gold of the weekend.