Claude Giroux and Scott Hartnell scored for the Flyers, who lost for just the second time at home in their last 14 games.
Tlusty beat Flyers goalie Steve Mason from close range high to the glove side with 6:10 remaining.
RED WINGS 5, BLACKHAWKS 4, SO
DETROIT • Darren Helm scored on Detroit's sixth attempt in the shootout and Jonas Gustavsson stopped Andrew Shaw's shot, lifting Detroit past Chicago.
The defending Stanley Cup champion Blackhawks faced Detroit for the first time since beating them in overtime in Game 7 of their second-round series last year to complete a comeback from a 3-1 deficit.
Chicago captain Jonathan Toews scored on his team's first attempt in the shootout and Patrick Sharp scored on the second before Patrick Kane was stopped with a chance to win the game.
Gustavsson, playing for the injured Jimmy Howard, made 31 saves in his first game in nearly a month.
Corey Crawford gave up four goals on the first 17 shots he faced and finished with 27 saves for the Blackhawks.
FLAMES 3, COYOTES 2
CALGARY, Alberta • Sean Monahan scored his team-leading 14th goal of the season and Matt Stajan got the game-winner as Calgary snapped its team-record seven-game home losing streak.
Lance Bouma also scored for Calgary, which scored more than two goals for the second time in 14 games since Christmas and had been outscored 22-4 during its home skid.
Karri Ramo finished with 30 saves for the Flames.
Antoine Vermette and Shane Doan scored for Phoenix, which has lost eight of its last 11.
PENGUINS 5, CANADIENS 1
PITTSBURGH • Jussi Jokinen scored twice and Pittsburgh cruised past Montreal.
Evgeni Malkin added a goal and an assist, Sidney Crosby picked up his 26th of the season and Taylor Pyatt added a rare score for the Penguins. Marc-Andre Fleury made 22 saves as Pittsburgh bounced back from a dismal loss to Florida on Monday by trouncing hapless Montreal.
Jokinen picked up his third multi-goal game of the season
Rene Bourque had his seventh goal for the Canadiens but Montreal spent most of the night chasing the Penguins. Carey Price stopped just 16 of 21 shots before being pulled late in the second period. Montreal has lost four of six.