The Irish (34-0) head into their game against the Cowgirls (25-8) not only undefeated, but have been seriously challenged in only a few games.
The only games they failed to win by double digits were a seven-point victory at Virginia and a four-point win at Maryland.
Coach Muffet McGraw said the key to the Irish success is they haven't focused on the big picture.
"We've just really embraced where we are in the journey and enjoyed each step of it. I think the most pressure was getting back home" for the regional semifinals, McGraw said.
The Cowgirls opened the season 12-0, the best start in school history, and got to a 17-1, but then didn't win consecutive games until beating Florida Gulf Coast and Purdue in the first two rounds of the NCAA tournament. But Littell said the Cowgirls are where they want to be.
"Right now we're playing our best basketball of the year. That's the time of year to be doing it," he said.
Women's NCAA Tournament
Saturday's Sweet 16 games
• UConn (36-0) vs. BYU (28-6), 2:30 p.m., ESPN
• DePaul (29-6) vs. Texas A&M (26-8), 5 p.m., ESPN
Notre Dame Region
• Kentucky (26-8) vs. Baylor (31-4), 10 a.m., ESPN
• Notre Dame (34-0) vs. Oklahoma State (25-8), 12:30 p.m., ESPN