The latest win for best lead actress in a play also makes McDonald the first grand-slam performance winner. She previously won as best featured actress in a play ("A Raisin in the Sun" and "Master Class"), best lead actress in a musical ("The Gershwins' Porgy and Bess") and best featured actress in a musical ("Ragtime" and "Carousel").
Cranston in a role far from TV's chemistry teacher-turned-meth kingpin Walter White in "Breaking Bad" won the best lead actor for playing former President Lyndon B. Johnson in Robert Schenkkan's "All the Way," which also was crowned best play.
Hugh Jackman kicked off the show with a bounce, hopping up and down like a kangaroo during his opening number Sunday. Big, high-kicking musical numbers from "After Midnight," ''Aladdin," ''Rocky" and "Hedwig and the Angry Inch" kept the energy level up but no clear overall winning show had yet emerged.
The bearded Australian, back as host after a nine-year absence, greeted many of the night's featured performers as he cheerfully bounded past them backstage. He then joined the cast of the musical "After Midnight" for a rousing rendition of "It Don't Mean a Thing (If it Ain't Got that Swing)." He later rapped with LL Cool J and T.I. to a reworked song from "The Music Man."
The first award of the night was for best featured actor in a play and it went to Mark Rylance, who won his third Tony for playing the countess Olivia in "Twelfth Night." Rylance, who previously won for "Jerusalem" and "Boeing-Boeing," is also nominated for best lead actor honors for his evil title character in "Richard III."
The best featured actress in a musical Tony went to Lena Hall in "Hedwig and the Angry Inch," playing a woman who dresses as a man and plays Harris' boyfriend. Hall wished her dad a happy birthday and gave a shout-out to her soon-to-be-born niece. "Friendship is magic," she said. The show later won for best musical revival.
Harris performed a song from the show, looking unrecognizable in a miniskirt and blond feathered wig. He gave an audience member a lap dance and took Samuel L. Jackson's glasses away and licked them. Another highlight was songwriter Carole King singing with the cast of the show based on her early years "Beautiful: The Carole King Musical."
Darko Tresnjak won for directing the musical "A Gentleman's Guide to Love & Murder" and thanked his mother, a skydiver during World War II now too frail to be there. The musical also won for best book of a musical and costumes for a musical. Away from the cameras, the now-closed musical "The Bridges of Madison County" won for best score and best orchestration.
Kenny Leon won his first Tony for directing the revival of "A Raisin in the Sun." He thanked, among other, his star Denzel Washington, and the women in his life. He even managed to plug his next work, "Holler If Ya Hear Me."
One of his "Raisin" stars, Sophie Okonedo, won for best featured actress in a play. "I am loving it on Broadway," she said. She thanked producer Scott Rudin for believing that a "Jewish, Nigerian Brit" could play the iconic role of Ruth Younger. The show also won best play revival.
James Monroe Iglehart, who plays the manic Genie in "Aladdin," won for best featured actor in a musical and could barely contain his glee as he thanked a long list of people that included God and his wife.